What promising news for science, humanity and Cannabis! The human Endocannabinoid System and the Cannabis plant proven effective by research and science! What wonderful work! Another tip of the hat from HerbaReleaf to all of those involved in this news!
“The researchers found that a pair of hemp compounds — cannabigerolic acid, or CBGA, and cannabidiolic acid, CBDA — bind to the SARS-CoV-2 spike protein, blocking a vital step in the deadly bug’s path to infect people.”
“As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19.”
“Cannabinoid acids from hemp (Cannabis sativa) were found to be allosteric as well as orthosteric ligands with micromolar affinity for the spike protein. In follow-up virus neutralization assays, cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells by a pseudovirus expressing the SARS-CoV-2 spike protein and prevented entry of live SARS-CoV-2 into cells.”
“They are not controlled substances like THC, the psychoactive ingredient in marijuana, and have a good safety profile in humans. And our research showed the hemp compounds were equally effective against variants of SARS-CoV-2, including variant B.1.1.7 [Alpha], which was first detected in the United Kingdom, and variant B.1.351 [Beta], first detected in South Africa.”
“These compounds can be taken orally and have a long history of safe use in humans,” van Breemen said. “They have the potential to prevent as well as treat infection by SARS-CoV-2. CBDA and CBGA are produced by the hemp plant as precursors to CBD and CBG, which are familiar to many consumers.”
“The two compounds commonly found in hemp — called cannabigerolic acid, or CBGA, and cannabidiolic acid, or CBDA — were identified during a chemical screening effort as having potential to combat coronavirus”